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    Groundbreaking development in the field of Diabetes with Dr Emran Khan

    Before getting into the nitty-gritty of the video, let us try to understand what diabetes is all about, its types and symptoms.

    The hormone insulin moves sugar from the blood into your cells to be stored or used for energy. Diabetes mellitus, commonly referred to as diabetes, is a metabolic disease when your body either does not make enough insulin or cannot effectively use the insulin it does make.

    If you have diabetes, your body isn’t able to properly process and use glucose from the food you eat. There are different types of diabetes, each with different causes, but they all share the common problem of having too much glucose in your bloodstream. Treatments include medications and/or insulins. Some types of diabetes can be prevented by adopting a healthy lifestyle.

    The different types of diabetes are:

    Type 1 Diabetes:  Once better known as juvenile diabetes, it is usually diagnosed in children and young adults. It is an autoimmune disease, meaning your body attacks itself as the insulin-producing cells in your pancreas are destroyed. People with Type 1 diabetes need to take insulin every day, which is why it is also called insulin-dependent diabetes.

    Type 2 Diabetes: This is the most common type of diabetes. Often referred to as adult-onset and insulin-resistant diabetes, it usually occurs in middle-aged and older people. In this case, the body does not make enough insulin or your body cells do not respond normally to the insulin. 

    Prediabetes: This is the stage before Type 2 diabetes where your blood glucose levels are higher but not high enough to be diagnosed with Type 2 diabetes.

    Gestational diabetes: This develops in women during their pregnancy and goes away after pregnancy. However, if you have gestational diabetes, you are at higher risk of developing Type 2 diabetes.

    Symptoms of diabetes include:• Increased thirst.• Weak, tired feeling.• Blurred vision.• Numbness or tingling in the hands or feet.• Slow-healing sores or cuts.• Unplanned weight loss.• Frequent urination.• Frequent unexplained infections.• Dry mouth.

    Other symptoms• In women: Dry and itchy skin, and frequent yeast infections or urinary tract infections.• In men: Decreased sex drive, erectile dysfunction, decreased muscle strength.

    Today, I am in conversation with Dr Emran Ghaffar Khan, whose speciality lies in Diabetes and Endocrinology. He is a Consultant Endocrinologist, Diabetologist (MBBS, MRCP( UK ), FRCP ( London, UK), and FRCP (Edinburgh, UK).In this video, we discuss the new groundbreaking development in the field of Diabetes while answering a few questions surrounding it.

    The latest development in the field of Diabetes:

    Dr Emran casts light on the discovery of a drug called Mounjaro, which is considered to be a groundbreaking development in the field of diabetes and also a game changer, as it turned out to be a great tool for helping patients with diabetes, particularly obesity.

    Does losing weight help cure Diabetes?

    Weight loss is an essential part of curbing diabetes. It cannot be the same for everyone, but in the majority of people, we witnessed a significant amount of weight loss, diabetes remission and reversal as well.

    How long does it take for the drug to start working?

    Mounjaro also referred to as Tirzepatide, is an injectable pen which can be used on your tummy or thigh with the press of a button. It works immediately, and the dose should be increased incrementally as 20% of people complained of nausea, 10% of bowel disturbance, diarrhoea or constipation. However, it is usually for the first two weeks then the body gets used to it.

    Insights about the drug:

    Drs. John Eng and Jean-Pierre Raufman found that a hormone in the venom of the Gila monster, a large lizard native to the southwestern United States, stimulates the body’s insulin production. Exenatide, a drug that is a synthetic form of a substance found in Gila monster’s saliva, led to healthy sustained glucose levels and progressive weight loss among people with type 2 diabetes who took part in a three-year study. This led to the invention of the drug Mounjaro.

    Mounjaro (tirzepatide) is a once-weekly injectable medication. It is the first and only dual GIP/GLP-1 receptor agonist.

    a glucose-dependent insulinotropic polypeptide (GIP)

    glucagon-like peptide-1 (GLP-1)

    Over the past few years, Mounjaro has shown to have a big impact on weight loss, A1c and cholesterol compared to its predecessors Trulicity, Ozempic, and Victoza. It is a dual-action GIP and GLP-1 that works as a single molecule to activate the body’s receptors for GIP and GLP-1 and helps to improve your diabetes health in a few ways:• It increases insulin production, but only when your blood sugar is rising, which makes the risk of low blood sugar minimal.• It decreases your liver’s production of sugar.• It slows down the speed at which your stomach empties food into your intestine. This helps manage your blood sugars after eating while also leaving you feeling full longer.

    Gradually, the drug became very popular through word of mouth, social media, and news articles. The Kings was the first Institute that had this drug available, and UAE was the first country to provide it. Later, with good feedback from the people, it was made available in the US.

    Does it work for everyone?

    One size doesn’t fit all. You need to sit with the patient and try to understand their calorie intake, and then based on that, will advise the medicines, and not necessary it is always the medicines which do the best bid.

    Is it very expensive?

    Yes, it is expensive. Although, it depends solely on the insurance companies. Type 2 diabetes, some insurance companies cover, and some do not. But, if you are a cash payer which most of his patients are, it costs around 1700 dirhams a month. As it is a weekly injection, you get a pack of 4 each costing around 420 dirhams which is equivalent to spending on a good meal in a restaurant or a movie in a theatre. 

    How long do you have to stay on it?

    You get a lot of benefits like cholesterol, blood pressure, and weight loss management. It also suppresses your appetite as it slows the stomach to empty by keeping the food in it for longer and gives the brain the signal that the stomach is full, and when you eat less, you lose weight and vice versa. The bariatric procedure does the same. Also, their cravings go away. You just don’t feel hungry as your stomach is full, hence the benefit of weight loss.

    Is it possible that your body gets used to it and it stops working for you?

    The effect of the drug remains as long as you take it. You are what you eat, and once you are in it for x number of months, it evanishes the craving habits and continues to keep the weight down without being on medication.

    How much does Bariatric surgery cost?

    Surgery costs around 25000 dirhams to 30000 dirhams. The prices are uniform irrespective of the dosage. The surgery may not suit everyone, Though it gives excellent results, it comes with its complications and it’s another choice for doctors and patients to benefit from.

    How does one start this journey?

    What kind of Doctor must they visit?

    The endocrinologist asses you and prescribe the medicines for controlling diabetes. It is not just a prescription, but more of an art where you want your patient you rely on you and trust you with the process.

    The team of Doctors at King’s College Hospital, Dubai

    The team comprises 5 endocrinologists who all are UK Trained it is a new drug for everyone, but it is a better drug controlling diabetes and obesity.

    Can this drug be used for weight loss without having Diabetes?

    Predecessors to Monjuaro, Ozempic, Trulicity, and Victoza were licensed for Type 2 diabetes, and later licenses were given for weight loss. So once the license is given out, it can be used solely for weight loss. The best judge is the endocrinologist who weighs in on the problems and can be prescribed to people with non-diabetes as it helped them with their weight loss.

    Mother of two grown-up children and wife, for nearly thirty years of a now retired, senior British Army officer. Modelling for the first time at the age of 53 she led a full-page campaign in eight editions of British Vogue, and in Tatler, Hello and White Magazines.

    Mother of two grown-up children and wife, for…

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